Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.

  • July 5, 2018
Cell Stem Cell. 2018 Jul 5;23(1):101-113.e7. doi: 10.1016/j.stem.2018.05.027. Epub 2018 Jun 28

 

Highlights

  • A protocol mimicking liver development enables generation of HSCs from hPSCs

  • iPSC-HSCs possess properties similar to those of their in vitro counterparts

  • iPSC-HSCs can form liver spheroids when aggregated with hepatocytes

  • Liver spheroids can be used to model fibrosis and liver toxicity