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Publications 2000-2004

1) by Albert Geerts (2000-2004)

Guest editorship

The Anatomical Record. Part A : Discoveries in molecular, cellular and evolutionary biology.Special Issue : The Hepatic Nervous System. Guest Editors : J.-P. Timmermans and A.Geerts. Anat Rec, part A, 2004, vol.280A, n°1 [IF2004 = 3.1]

Publications in scientific journals 2000-2004

1. Louis, H., Le Moine A.., Quertinmont,E., Wu, W., Peny M.-O.., Geerts A.., Goldman M., Le Moine O., Deviere, J. 2000. Chronic in vivo stimulation with concanavalin A induces IL-10 producing phenotype and liver fibrosis. Hepatology, 31(2):381-90. [IF2002 = 9.8]
2. Beljaars L., Molema G., Schuppan D., Geerts A., De Bleser P., Weert B., Meijer D., Poelstra K. 2000. Succesful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor. J Biol Chem. , 275(17):12743-51. [IF2003 = 6.5]
3. Van den Branden,C., Ceyssens,B., De Craemer, D., De Bleser, P., Hellemans, K., Geerts, A., Verbeelen, D. 2000. Anti-oxidant enzyme gene expression in rats with remnant kidney induced chronic liver failure, Exp Nephrol, 8(2):91-6, 2000. [IF2001 = 1.9]
4. Van den Branden,C., Ceyssens,B., De Craemer, D., Vanden Houte, K., De Bleser, P., Hellemans, K., Geerts, A., Verbeelen, D. 2000. Renal anti-oxidant enzymes and fibrosis-related markers in the rat adriamycin model. Nephron., 86, 167 - 175. [IF2001 = 1.8]
5. Wilczak N., De Bleser P., Luiten P., Geerts A., Teelken A., De Keyser J. 2000. Insulin-like growth factor II receptors in human brain and their absence in astrogliotic plaques in multiple sclerosis. Brain Research, . 863 : 282-288. [IF2001 = 2.5]
6. Reynaert, R , A. Burt , A. Geerts. 2000. Prions in stellate cells : not a surprise after all.(Editorial on invitation). J Hepatol, 33, 838 - 841. [IF2002 = 5.0]
7. Rombouts, T. Niki, A. Wielant, K. Hellemans, K., Schuppan, S., Kormoss N., Geerts A. Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells. 2001. J Hepatol, 34, 230 - 238. [IF2002 = 5.0]
8. Geerts A., Niki T., Eliasson C., Wielant A., Vaeyens F., Pekny M. Formation of normal desmin intermediate filaments in mouse hepatic stellate cells requires vimentin. 2001.Hepatology, 33, 177 - 188. (Fig. 7b of paper has appeared on the cover of Jan. issue of Hepatology). [IF2002 = 9.8]
9. R. Bataller, X. Gasull, P. Ginès, K. Hellemans, M. Nieves Görbig, J. Nicolás, P. Sancho-Bru, A. Gual, A. Geerts, V. Arroyo, J. Rodés. 2001. In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage operated calcium channels (accompanied by Editorial written by Y. Lee). Hepatology, 33, 956 - 962. [IF2002 = 9.8]
10. Vanhaecke T., Foriers A, Geerts A., Shephard E., Vercruysse A., Rogiers V. Pyruvate-induced long-term maintenance of glutathione s-transferase in rat hepatocyte cultures. 2001. Altern Lab Anim., 29:335-46. [IF2003 = 2.0]
11. Rombouts, K., Schuppan S., Kormoss N., Geerts A. Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts. 2001. British Journal of Pharmacology, 134, 224 - 232. [IF2002 = 3.5]
12. Reynaert H., Vaeyens F., Qin H., Hellemans K., Chatterjee N., Winand D., Quartier E., Schuit F., Urbain D., Patel Y., A. Geerts. 2001. Somatostatin suppresses endothelin-1 induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1. Gastroenterology, 121, 915 - 930. [IF2002 = 13.4]
13. Beljaars L., Olinga P., Molema G., De Bleser P., Geerts A., Groothuis G., Meijer D., Poelstra K. 2001. Charactristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P28-HSA). Liver , 21 , 320 - 328. [IF2002 = 2.4]
14. Reynaert H., Chavez M., Geerts A. 2001. Vascular endothelial growth factor and liver regeneration (Editorial on invitation). J Hepatol, 34, 759 - 761. [IF2002 = 5.0]
15. Geerts A.. History, heterogeneity, developmental biology and functions of quiescent hepatic stellate cells. 2001. Seminars in Liver Disease, 21, 311 - 335. [IF2002 = 6.0]
16. Reynaert, H., Thompson M., Thomas T., Geerts A. Hepatic stellate cells : role in microcirculation and pathophysiology of portal hypertension. 2002. Gut, 571-581, 2002. [IF2003 = 5.9]
17. Herold, C., Ganslmayer, M., Ocker, M., Hermann, M., Geerts, A., Hahn,E., Schuppan,D. 2002. The histone deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. 2002. J Hepatol, 36, 233 - 240. [IF2003 = 5.3]
18. Demols, A., J.-L. Van Laethem, E. Quertimont, C. Degraef, M. Delhaye, A. Geerts, J. Devière. 2002. Endogenous interleukin-10 modulated fibrogenesis after repeated acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol, 282, G1105-1112. [IF2003 = 3.4]
19. Wilczak, N., Kuhl N., Chesik D., A. Geerts, P. Luiten and J. De Keyser. 2002. Insulin-like growth factor (IGF)-I binding to a cell membrane associated IGF binding protein-3 acid-labile subunit complex in human anterior pituitary gland. J Neurochem, 82, 430 - 438. [IF2003 = 4.8]
20. Rombouts K., T. Knittel, L. Machesky, F. Braet, A. Wielant, K. Hellemans, P. de Bleser, I. Gelman, G. Ramadori, and A. Geerts. Actin filament formation, reorganisation and migration are impaired in liver hepatic stellate cells under the influence of Trichostatin A, a histone deacetylase inhibitor. 2002. J Hepatol, 37, 788-796. (Fig. 5d has apeared on the cover of the Dec. issue of J. Hepatol.). [IF2003 = 5.3]
21. Rombouts K, T. Niki, P. Greenwel, A. Vandermonde, A. Wielant, K. Hellemans, P. De Bleser, M. Yoshida, D. Schuppan, M. Rojkind, A. Geerts. Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res 2002; 278:184-97. [IF2003 = 3.9]
22. Hellemans K., Michalik L., Dittié A., Knorr A., Rombouts K., De Jong J., Heirman C., Quartier E., Schuit F., Wahli W., Geerts A. PPAR drives transdifferentiation of stellate cells into myofibroblasts. 2003. Gastroenterology, 124, 184 - 201. . [IF2004 = 13.1]
23. Caligiuri, A. De Franco, R. Romanelli, A. Gentilini, M. Meucci, P. Failli, L. Mazitti, K. Rombouts, A. Geerts, M. Vanasia, P. Gentilini, F. Marra and M. Pinzani. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology, 2003, 124, 504 - 520. [IF2004 = 13.1]
24. Hellemans K., Rombouts K., Quartier E., Dittié A., Knorr A., Michalik L., Rogiers V., Schuit F., Wahli W., Geerts A. PPAR regulates vitamin A metabolism-related gene expression. J. Lipid Research, 2003, 44, 280-295. . [IF2004 = 4.2]
25. Rombouts, K., Kisanga E., Hellemans K., Schuppan S., Geerts A. Effect of HMG CoA Reductase inhibitors on proliferation and ECM expression by rat hepatic stellate cells. J Hepatol, 38, 564-572, 2003. . [IF2004 = 4.8]
26. H. Reynaert, Sermon, F., Urbain, D., Geerts A. Stellate cells in the digestive tract. Current Gastroenterology Reports, 5, 177 - 179, 2003.
27. H. Reynaert, A. Geerts. Pharmacological Rationale for the use of somatostatin and analogues in portal hypertension. Alimentary Pharmacology and Therapeutics, 2003;18(4):375-86. . [IF2004 = 4.0]
28. Papeleu, P., Loyer, P., Vanhaecke, T., Elaut, G., Geerts, A., Guguen-Guillouzo, C. and V. Rogiers. Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes. J Hepatol, 39, 374 - 382, 2003. . [IF2004 = 4.8]
29. Beljaars L., Weert B., Geerts A., Meijer D., Poelstra K. The preferential homing of platelet derived growth factor receptor - recognizing macromolecule to fibroblast-like cells in fibrotic tissue. Biochemical Pharmacology, 66, 1307 - 1317, 2003. . [IF2004 = 3.4]
30. Hellemans, K., Verbuyst, P., Quartier,E., Schuit, F., Rombouts, K., Chandraratna, R., Schuppan, D., Geerts, A. Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids. Hepatology, 39, 97 - 108, 2004. . [IF2004 = 10.4]
31. Geerts, A. On the origin of stellate cells : mesodermal, endodermal or neuro-ectodermal ? Editorial on invitation. J Hepatol, 2004, 40(2),:331-4.. . [IF2004 = 4.8]
32. Reynaert, H., Rombouts, K., Vandermonde, A., Urbain, D., Kumar, U., Bioulac-Sage, P., Pinzani, M., Rosenbaum, J., A. Geerts. Expression of somatostatin receptor subtypes in human cirrhosis and hepatocellular carcinoma, GUT, 53, 1180 - 1189, 2004. . [IF2004 = 6.6]
33. Albert GEERTS. Nerve supply and nervous control of liver function : foreword.. Anat Rec., part A, 280A, 805 - 806, 2004. [IF2004 = 3.1]
34. Neural connections between the hypothalamus and the liver. Naoki UYAMA, Albert GEERTS and Hendrik REYNAERT, Vrije Universiteit Brussel, Belgium. Anat Rec., part A, 280A, 808 - 820, 2004. [IF2004 = 3.1]

Publications in Books / Proceedings / National Journals 2000-2004

1. K. Rombouts, T. Knittel, A. Wielant, K. Hellemans, L. Machesky, I. Gelman, G. Ramadori and A Geerts. Effect of trichostatin A, a histone deacetylase inhibitor, on proteins of the actin cytoskeleton of rat hepatic stellate cells. Cells of the Hepatic Sinusoid, Kupffer Cell Foundation, 2001, Vol. 8, p. 271-273. Editors : Wisse E., Knook D.L, De Zanger R and M. Arthur. 
2. K. Hellemans, K. Rombouts, F. Schuit, L. Michalik, W. Wahli and A. Geerts. The retinol - esterifying hepatic stellate cell : model for PPAR - signaling. Cells of the Hepatic Sinusoid, Kupffer Cell Foundation, 2001, Vol. 8, p. 212-214. Editors : Wisse E., Knook D.L., De Zanger R and M. Arthur.
3. K. Rombouts, T. Niki, A. Wielant, K. Hellemans, and A. Geerts. Trichostatin A, lead compound for development of antifibrogenic drugs (review paper). 2001. Acta Gastro-Enterologica Belgica, 64, 239 - 246.
4. Reynaert H., Vaeyens F., Qin H., Hellemans K., Chatterjee N., Winand D., Quartier E., Schuit F., Urbain D., A. Geerts. Activated rat hepatic stellate cells bear functional somatostatin receptors. Cells of the Hepatic Sinusoid, Kupffer Cell Foundation, 2001, Vol. 8, p. 187-190. Editors : Wisse E., Knook D.L., De Zanger R and M. Arthur. 
5. Rombouts K, Niki T, Yoshida M, Geerts A. Role of histone deacetylases in transcriptional control of the hepatic stellate cell phenotype. In: Extracellular matrix & the Liver :Approach to Gene Therapy. Academic Press, 2003, p190-206. Editors: Okazaki I., Ninomiya Y., Friedman S., Tanikawa K.


2) By Leo A. van Grunsven (2000-2004)

van Grunsven LA, Papin C, Avalosse B, Opdecamp K, Huylebroeck D, Smith JC, Bellefroid EJ. XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development. 2000 Jun;94(1-2):189-93.

van Grunsven LA, Schellens A, Huylebroeck D, Verschueren K. SIP1 (Smad interacting protein 1) and deltaEF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S40-7. Review.

Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, Mareel M, Huylebroeck D, van Roy F. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell. 2001 Jun;7(6):1267-78.

Zwijsen A, van Grunsven LA, Bosman EA, Collart C, Nelles L, Umans L, Van de Putte T, Wuytens G, Huylebroeck D, Verschueren K. Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo. Mol Cell Endocrinol. 2001 Jun 30;180(1-2):13-24. Review.

Papin C, van Grunsven LA, Verschueren K, Huylebroeck D, Smith JC. Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1. Mech Dev. 2002 Feb;111(1-2):37-46.

van Grunsven LA, Huylebroeck D, Verschueren K. Complex Smad-dependent transcriptional responses in vertebrate development and human disease. Crit Rev Eukaryot Gene Expr. 2002;12(2):101-18. Review.

van Grunsven LA, Michiels C, Van de Putte T, Nelles L, Wuytens G, Verschueren K, Huylebroeck D. Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin. J Biol Chem. 2003 Jul 11;278(28):26135-45. Epub 2003 Apr 24.

Caron C, Pivot-Pajot C, van Grunsven LA, Col E, Lestrat C, Rousseaux S, Khochbin S. Cdyl: a new transcriptional co-repressor. EMBO Rep. 2003 Sep;4(9):877-82. Epub 2003 Aug 8.

Nelles L, Van de Putte T, van Grunsven L, Huylebroeck D, Verschueren K. Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1. Genomics. 2003 Oct;82(4):460-9.

Pirot P, van Grunsven LA, Marine JC, Huylebroeck D, Bellefroid EJ. Direct regulation of the Nrarp gene promoter by the Notch signaling pathway. Biochem Biophys Res Commun. 2004 Sep 17;322(2):526-34.