Publications 2005-2009

by CYTO & LIVR members

Guest editorship

The Anatomical Record (Hoboken) - Special Issue : Hepatic Circulation. Guest Editors : A Geerts, J.-P. Timmermans and H. Reynaert. Anat Rec (Hoboken), 2008, vol.291, issue 6.

Publications in scientific journals 2005-2009

Haentjens P, Massaad D, Reynaert H, Peeters E, Van Meerhaeghe A, Vinken S, Poppe K, Velkeniers B. Identifying non-alcoholic fatty liver disease among asymptomatic overweight and obese individuals by clinical and biochemical characteristics. Acta Clin Belg. 2009 Nov-Dec;64(6):483-93

Reynaert H, Dujardyn M, Urbain D. A star-spangled liver. Liver Int. 2009 Sep 11. [Epub ahead of print]

Fraczek J, van Grunsven LA, Vinken M, Snykers S, Deleu S, Vanderkerken K, Vanhaecke T, Rogiers V. Histone Deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology. J Cell Mol Med. 2009 Jul 6.

Vermeire L, Ibrahimi A, Voet T, Umans L, Coddens K, Francis A, Van de Putte T, van Grunsven LA, Zwijsen A, Huylebroeck D, Nelles L. Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap. Int J Dev Biol. 2009;53(7):1045-51

Macken E, Moreels T, Pelckmans P, Peeters M, Baert D, Reynaert H, Delooze D, Vannoote J, Hiele M, Coenegrachts JL, Hoste P, Van Cutsem E, D' Haens G. Quality assurance and recommendations for quality assessment of screening colonoscopy in Belgium. Acta Gastroenterol Belg. 2009;72:17-25.

Vandenplas Y, Hauser B, Devreker T, Urbain D, Reynaert H. A Biodegradable Esophageal Stent in the Treatment of a Corrosive Esophageal Stenosis in a Child. J Pediatr Gastroenterol Nutr. 2009;49:254-257.

Snykers S, Henkens T, De Rop E, Vinken M, Fraczek J, De Kock J, De Prins J, Geerts A, Rogiers V and Vanhaecke T. (2009) Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation, and stem cell reprogrammation. J Hepatol, 2009, Jul;51(1):187-211. Epub 2009 Apr 2

Van Rossen E, Vander Borght S, van Grunsven LA, Reynaert H, Bruggeman V, Blomhoff R, Roskams T and Geerts A. Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver. Histochem Cell Biol. 2009 Mar;131(3):313-25. Epub 2008 Dec 4.

Lemmers A, Gustot T, Durnez A, Evrard S, Moreno C, Quertinmont E, Vercruysse V, Demetter P, Franchimont D, Le Moine O, Geerts A, Deviere J. An inhibitor of interleukin-6 trans-signalling, sgp130, contributes to impaired acute phase response in human chronic liver disease. Clinical and Experimental Immunology. 2009;156:518-527.

Lemmers A, Moreno C, Gustot T, Maréchal R, Degré D, Demetter P, de Nadai P, Geerts A, Quertinmont E, Vercruysse V, Le Moine O, Devière J. The Interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 2009 Feb;49(2):646-57.

Von Oppen N, Schurich A, Hegenbarth S, Stabenow D, Tolba R, Weiskirchen R, Geerts A, Kolanus W, Knolle P, Diehl L. Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization.. Hepatology, 2008, Dec 23; 49(5):1664-1672 [published online]

RA Hannivoort, S Dunning, S Vander Borght, M Buist-Homan, M Geuken, B Schroyen, A Geerts, T Roskams, KN Faber, H Moshage. Multidrug resistance-associated proteins are crucial for the viability of activated hepatic stellate cells. Hepatology, 2008 Aug;48(2):624-34.

Fraczek J, Deleu S, Lukaszuk A, Doktorova T, Tourwé D, Geerts A, Vanhaecke T, Vanderkerken K, Rogiers V. Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. Invest New Drug, 2009 Aug;27(4):338-46. Epub 2008 Sep 30

Verstappen G, van Grunsven LA, Michiels C, Van de Putte T, Souopgui J, Van Damme J, Bellefroid E, Vandekerckhove J, Huylebroeck D. Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex. Hum Mol Genet. 2008;17(8):1175-83. Epub 2008 Jan 8.

Van Beneden K, van Grunsven LA, Geers C, Pauwels M, Desmoulière A, Verbeelen D, Geerts A, Van den Branden C. CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis. Nephrol Dial Transpl, 2008 Nov;23(11):3464-71. [Epub 25 May 2008]

Deleu S, Fraczek J, Lukaszuk A, Doktorova TY, Tourwe D, Geerts A, Van Camp B, Vanhaecke T, Rogiers V, Vanderkerken K. Screening of Trichostin analogues based on cellular potency in the murine multiple 5T33MM model. Journal of Cancer Molecules. 2008;4(4):117-121.

Vandenplas Y, Hauser B, Devreker T, Urbain D, Reynaert H. A degradable esophageal stent in the treatment of a corrosive esophageal stenosis in a child. Endoscopy. 2009;41 Suppl 2:E73.

Andrade CM, Roesch GC, Wink MR, Guimarães EL, Souza LF, Jardim FR, Guaragna RM, Bernard EA, Margis R, Borojevic R, Battastini AM, Guma FC. Activity and expression of ecto-5'-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line. Life Sci. 2008;82(1-2):21-29.

Bechmann LP, Best J, Haag S, Leineweber K, Gerken G, Holtmann G. Serotonergic and Non-Serotonergic effects of two Tricyclic Antidepressants on Visceral Nociception in a Rat Model. Scand J Gastroenterol. 2008;44(6):680-686.

De Maeght S, Henrion J, Bourgeois N, De Galocsy C, Langlet P, Michielsen P, Reynaert H, Robaeys G, Sprengers D, Orlent H, Adler M. A pilot observational survey of hepatitis C in Belgium. Acta Gastroenterol Belg. 2008;71:4-8.

Sowa JP, Best J, Benko T, Bockhorn M, Gu Y, Bucchi A, Benedetto-Castro EM, Gerken G, Rauen U, Schlaak JF. Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration. World J Gastroenterol. 2008;14 (46):7093-7100.

Urbain D, Reynaert H, De Looze D. Capsule endoscopy findings in cirrhosis with portal hypertension: A prospective study. Dig Liver Dis. 2008;40:392.

Urbain D, Vandebosch S, Hindryckx P, Colle I, Reynaert H, Mana F, Vanden Branden S, Van Vlierberghe H, De Vos M, De Looze D. Capsule endoscopy findings in cirrhosis with portal hypertension: A prospective study. Dig Liver Dis 2008;40:392-393.

Geerts A, Timmermans J.-P., Reynaert H. Hepatic Circulation. Anat Rec (Hoboken), 2008 Jun;291(6):611-613

Reynaert H, Urbain D, Geerts A. Regulation of sinusoidal perfusion in portal hypertension.Regulation of sinusoidal perfusion in portal hypertension. Anat Rec (Hoboken), 2008 Jun;291(6):693-698.

Vanheule E, Geerts AM, Reynaert H, Van Vlierberghe H, Geerts A, De Vos M, Colle I. Influence of somatostatin and octreotide on liver microcirculation in an experimental mouse model of cirrhosis studies by intravital microscopy. Liver Int 2008 Jan;28(1):107-16

A. Geerts,. The simple truth is seldom true and never simple: dual role for p75(NTR) in transdifferentation and cell death of hepatic stellate cells. Hepatology. 2007 Aug;46(2):600-1.

H Reynaert , E van Rossen, N Uyama, N Chatterjee, U Kumar, D Urbain and A Geerts. Expression of somatostatin receptors in splanchnic blood vessels of normal and cirrhotic rats. Liver Int 2007 Aug;27(6):825-31.

van Grunsven LA, Taelman V, Michiels C, Verstappen G, Souopgui J, Nichane M, Moens E, Opdecamp K, Vanhomwegen J, Kricha S, Huylebroeck D, Bellefroid EJ. XSip1 neuralizing activity involves the co-repressor CtBP and occurs through BMP dependent and independent mechanisms. Dev Biol. 2007 Jun 1;306(1):34-49. Epub 2007 Mar 20.

Van de Putte T, Francis A, Nelles L, van Grunsven LA, Huylebroeck D. Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome. Hum Mol Genet. 2007 Jun 15;16(12):1423-36. Epub 2007 May 3.

Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Mechanisms and consequences of insulin resistance in liver cells. J Hepatol Jul;47(1):142-56. Epub 2007 Apr 16

Bockhorn M, Frilling A, Benko T, Best J, Sheu SY, Trippler M, Schlaak JF, Broelsch CE. Tri-iodothyronine as a stimulator of liver regeneration after partial and subtotal hepatectomy Eur Surg Res. 2007;39(1):58-63.

Colle I, Adler M, Brenard R, Henrion J, Langlet P, Michielsen P, Orlent H, Reynaert H, Sprengers D, Stärkel P, Van Damme P, Verslype C, Delwaide J. Management and treatment of Chronic Hepatitis B virus: Belgian Association for the Study of the Liver 2007 guidelines. Acta Gastroenterol Belg. 2007;70:389-420.

de Souza LF, Barreto F, da Silva EG, Andrades ME, Guimarães EL, Behr GA, Moreira JC, Bernard EA. Regulation of LPS stimulated ROS production in peritoneal macrophages from alloxan-induced diabetic rats: involvement of high glucose and PPARgamma. Life Sci. 2007;81(2):153-159.

Guimarães EL, Franceschi MF, Andrade CM, Guaragna RM, Borojevic R, Margis R, Bernard EA, Guma FC. Hepatic stellate cell line modulates lipogenic transcription factors. Liver Int. 2007;27(9):1255-1264.

Peeters L, Sanders NN, Demeester J, De Smedt SC. Challenges in nonviral ocular gene transfer. Biochem Soc Trans. 2007;35(Pt 1):47-49.

Peeters L, Sanders NN, Jones A, Demeester J, De Smedt SC. Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells. J Control Release. 2007;121(3):208-217.

Peeters L, Sanders NN, Lentacker I, Demeester J, De Smedt SC. Wanted and unwanted properties of surface pegylated nucleic acid nanoparticles in ocular gene transfer.J Control Release. 2007;122(3):226-35.

Van Laer W, Urbain D, Reynaert H. Esophageal intramural pseudodiverticulosis: a rare cause of dysphagia. Clin Gastroenterol Hepatol. 2007;5:A22.

Verset G, Verslype C, Reynaert H, Borbath I, Langlet P, Vandebroek A, Peeters M, Houbiers G, Francque S, Arvanitakis M, Van Laethem JL. Efficacy of the combination of long-acting release octreotide and tamoxifen in patients with advanced hepatocellular carcinoma: a randomised multicentre phase III study. Br J Cancer. 2007;97:582-588.

Vinken M, Henkens T, Vanhaecke T, Papeleu P, Geerts A, Van Rossen E, Chipman JK, Meda P, Rogiers V. Trichostatin A Enhances Gap Junctional Intercellular Communication in Primary Cultures of Adult Rat Hepatocytes. Toxicol Sci. 2006 Jun;91(2):484-92 (2006 Mar 10; [Epub ahead of print]).

Dollé L, Depypere HT, Bracke ME. Anti-invasive/anti-metastasis strategies: new roads, new tools and new hopes..Curr Cancer Drug Targets. 2006 Dec;6(8):729-51.

Srahna M, van Grunsven LA, Remacle JE, Vandenberghe P.CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription. Immunology. 2006 Mar;117(3):396-401

van Grunsven, L. A., Taelman, V., Michiels, C., Opdecamp, K., Huylebroeck, D., and Bellefroid, E. J. (2006). deltaEF1 and SIP1 are differentially expressed and have overlapping activities during Xenopus embryogenesis. Dev Dynam 2006 Jun;235(6):1491-500.

Adam B, Liebregts T, Best J, Bechmann L, Lackner C, Neumann J, Koehler S, Holtmann G. A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model. Scand J Gastroenterol. 2006;41(2):155-160.

Bechmann LP, Best J, Jochum C, Treichel U, Gerken G, Canbay A. Crohn's disease-induced non-alcoholic fatty liver disease (NAFLD) sensitizes for severe acute hepatitis B infection and liver failure. Z Gastroenterol. 2006;44(3):245-248.

Guimarães EL, Franceschi MF, Grivicich I, Dal-Pizzol F, Moreira JC, Guaragna RM, Borojevic R, Margis R, Guma FC.
Relationship between oxidative stress levels and activation state on a hepatic stellate cell line. Liver Int. 2006;26(4):477-485.

Reynaert H, Van Vlierberghe H, Op De Beeck B, Roskams T. Management of small focal liver lesions in a cirrhotic liver: discussion. Acta Gastroenterol Belg. 2006;69:236-237.

Uyama N, Zhao L, Van Rossen E, Hirako Y, Reynaert H, Adams DH, Xue Z, Li Z, Robson R, Pekny M, and Geerts A. Hepatic stellate cells express synemin, a protein bridging intermediate filaments to focal adhesions. GUT, Published Online First: 16 February 2006.

Reynaert H, Geerts A and Henrion J; The treatment of non-alcoholic steatohepatitis with thiazolidinediones. Aliment Pharm Therap. 2005 Nov 15;22(10):897-905

Kochaji N, Goossens A, Geerts A Bottenberg P. PTCH expression in odontogenic cysts, a cause of pathogenesis or reason for clinical complication. Oral Oncology (Extra), 2005; 41: 284-288.

J.-P. Timmermans and A. Geerts. Nerves in liver: superfluous structures? A special issue of The Anatomical Record updating our views on hepatic innervation. Anat Rec B New Anat. 2005 Jan;282(1):4.

H. Reynaert, K. Rombouts, Y. Jia , D. Urbain, N. Chatterjee, N. Uyama, A. Geerts. Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells. Brit J Pharmacol 2005, 27: 77-88.

Collart, C., Remacle, J. E., Barabino, S., van Grunsven, L. A., Nelles, L., Schellens, A., Van de Putte, T., Pype, S., Huylebroeck, D., and Verschueren, K. (2005). Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. Genes Cells 10, 897-906.

Hublitz, P., Kunowska, N., Mayer, U. P., Muller, J. M., Heyne, K., Yin, N., Fritzsche, C., Poli, C., Miguet, L., Schupp, I. W., van Grunsven, L.A., Potiers N, van Dorsselaer A, Metzger E, Roemer K, Schüle R.(2005). NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Gene Dev 19, 2912-2924.

van Grunsven, L. A., Verstappen, G., Huylebroeck, D., and Verschueren, K. (2005). Smads and chromatin modulation. Cytokine & Growth Factor Reviews 16, 495-512.

De Vogelaere K, Buydens P, Reynaert H, Vanhoey M, Delvaux G. Laparoscopic Wedge Resection for Gastric Ectopic Pancreas. Surg Laparosc Endosc Percutan Tech. 2005;15(3):166-168.

Peeters L, Sanders NN, Braeckmans K, Boussery K, Van de Voorde J, De Smedt SC, Demeester J. Vitreous: a barrier to nonviral ocular gene therapy. Invest Ophthalmol Vis Sci. 2005;46(10):3553-3561.

Dollé L, Oliveira MJ, Bruyneel E, Hondermarck H, Bracke M. Nerve growth factor mediates its pro-invasive effect in parallel with the release of a soluble E-cadherin fragment from breast cancer MCF-7/AZ cells. J Dairy Res. 2005;72 Spec No:20-6.

Robaeys G, Buntinx F, Bottieau E, Bourgeois S, Brenard R, Colle I, De Bie J, Mathei C, Mulkay JP, Van Damme P, Van Ranst M, Verrando R, Michielsen P, Bourgeois N, Brenard R, de Galocsy Ch, Delwaide J, Henrion J, Horsmans Y, Michielsen P, Reynaert H, Robaeys G, Sprengers D; Steering Committee of the Belgian Association for the Study of the Liver (BASL). Guidelines for the management of chronic hepatitis C in patients infected after substance use. Acta Gastroenterol Belg. 2005;68:38-45.

Rehrer NJ, Goes E, DuGardeyn C, Reynaert H, DeMeirleir K. Effect of carbohydrate on portal vein blood flow during exercise. Int J Sports Med. 2005;26:171-176.

Van Vlierberghe H, Colle I, Henrion J, Michielsen P, Delwaide J, Reynaert H, Borbath I, Martinet JP, Sprengers D, Brenard R. The HepCar registry: report on a one-year registration program of hepatocellular carcinoma (HCC) in Belgium. What is daily practice in HCC? Acta Gastroenterol Belg. 2005;68:403-411.

Verslype C, Michielsen P, Adler M, Orlent H, Sprengers D, Delwaide J, D'heygere F, Langlet P, Brenard R, Colle I, Reynaert H, Starkel P, Henrion J. Steering. Committee of the Belgian Association for the Study of the Liver. The management of patients with mild hepatitis C. Acta Gastroenterol Belg. 2005;68:314-318.

Publications in Books 2005-2009

H. Reynaert, N. Uyama and A. Geerts. Contribution of Hepatic Stellate Cells to the Regulation of Intrahepatic Microcirculation and the Pathophysiology of Portal Hypertension. In: Hypertension: New research. p105-139, 2005, Nova Science Publishers Inc. Editor: E.F. Benhagen, ISBN I-59454-204-X
A. Geerts and M. Pekny. Hepatic Stellate Cells and Astrocytes: Similarities and Differences. In: Hepatic Encephalopathy and Nitrogen Metabolism. Springer 2006. Häussinger, D.; Kirchels, G.; Schless, F. (Eds.), Hardcover ISBN: 1-4020-4455-0.