Cell Stem Cell. 2018 Jul 5;23(1):101-113.e7. doi: 10.1016/j.stem.2018.05.027. Epub 2018 Jun 28
Highlights
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A protocol mimicking liver development enables generation of HSCs from hPSCs
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iPSC-HSCs possess properties similar to those of their in vitro counterparts
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iPSC-HSCs can form liver spheroids when aggregated with hepatocytes
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Liver spheroids can be used to model fibrosis and liver toxicity