Publications LIVR 2010-present

Publications LIVR (most recent to 2010)

The orphan receptor GPR176 in hepatic stellate cells exerts a profibrotic role during chronic liver diseases. Vincent De Smet, Elif Gürbüz, Nathalie Eysackers, Liza Dewyse, Ayla Smout, Mina Kazemzadeh Dastjerd, Pierre Lefesvre, Nouredin Messaoudi, Hendrik Reynaert, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven. Available online 8 February 2024 : https://doi.org/10.1016/j.jhepr.2024.101036 or https://www.jhep-reports.eu/article/S2589-5559(24)00037-5/fulltext

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling.
Chui JS, Izuel-Idoype T, Qualizza A, de Almeida RP, Piessens L, van der Veer BK, Vanmarcke G, Malesa A, Athanasouli P, Boon R, Vriens J, van Grunsven L, Koh KP, Verfaillie CM, Lluis F.
Adv Sci (Weinh). 2023 Dec 1:e2307554. doi: 10.1002/advs.202307554. Online ahead of print.

Spatially Self-Organized Three-Dimensional Neural Concentroid as a Novel Reductionist Humanized Model to Study Neurovascular Development.
Chai YC, To SK, Simorgh S, Zaunz S, Zhu Y, Ahuja K, Lemaitre A, Ramezankhani R, van der Veer BK, Wierda K, Verhulst S, van Grunsven LA, Pasque V, Verfaillie C.
Adv Sci (Weinh). 2023 Nov 30:e2304421. doi: 10.1002/advs.202304421. Online ahead of print.

Thyroid hormone receptor alpha modulates fibrogenesis in hepatic stellate cells.
Manka P, Coombes JD, Sydor S, Swiderska-Syn MK, Best J, Gauthier K, van Grunsven LA, Oo YH, Wang C, Diehl AM, Hönes GS, Moeller LC, Figge A, Boosman RJ, Faber KN, Tannapfel A, Goetze O, Aspichueta P, Lange CM, Canbay A, Syn WK.
Liver Int. 2023 Oct 23. doi: 10.1111/liv.15759. Online ahead of print.

Generation and Culture of Primary Mouse Hepatocyte-Hepatic Stellate Cell Spheroids.
Mannaerts I, Eysackers N, van Grunsven LA.
Methods Mol Biol. 2023;2669:193-206. doi: 10.1007/978-1-0716-3207-9_11.

Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.
Muturi HT, Ghadieh HE, Abdolahipour R, Stankus HL, Belew GD, Liu JK, Jahromi MS, Lee AD, Singer BB, Angeli-Pahim I, Sehrawat TS, Malhi H, Verhulst S, van Grunsven LA, Zarrinpar A, Duarte S, Najjar SM.
Metabolism. 2023 Jul;144:155562. doi: 10.1016/j.metabol.2023.155562. Epub 2023 Apr 21.

W Kowalczyk, L Romanelli, M Atkins, H Hillen, C Bravo González-Blas, J Jacobs, J Xie, S Soheily, E Verboven I M Moya, S Verhulst, M de Waegeneer, L Sansores-Garcia, L van Huffel, R L Johnson, L A van Grunsven, S Aerts, G Halder. Hippo signaling instructs ectopic but not normal organ growth. Science. 2022 Nov 18;378(6621):eabg3679. doi: 10.1126/science.abg3679. Epub 2022 Nov 18.

van Os EA, Cools L, Eysackers N, Szafranska K, Smout A, Verhulst S, Reynaert H, McCourt P, Mannaerts I, van Grunsven LA. Modelling fatty liver disease with mouse liver-derived multicellular spheroids. Biomaterials. 2022 Nov;290:121817. doi: 10.1016/j.biomaterials.2022.121817. Epub 2022 Sep 28.

Thienpont A, Verhulst S, Van Grunsven LA, Rogiers V, Vanhaecke T, Mertens B. Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells. ALTEX. 2022 Nov 4. doi: 10.14573/altex.2206201. Online ahead of print.

Dewyse L, De Smet V, Verhulst S, Eysackers N, Kunda R, Messaoudi N, Reynaert H, van Grunsven LA. Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis. doi.org/10.3389/fmed.2022.862185. Front. Med., 30 March 2022

Lalor PF, Huser T, van Grunsven LA. Editorial: Roles of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease. Front Physiol. 2022 Mar 8;13:869473. doi: 10.3389/fphys.2022.869473. eCollection 2022.

Bednarczyk E, Lu Y, Paini A, Batista Leite S, van Grunsven LA, Worth A, Whelan M. Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model. Altern Lab Anim. 2022 Mar 3:2611929221082200. doi: 10.1177/02611929221082200. Online ahead of print.

Xiaojie Yu, Natalia Elfimova, Marion Müller, Daniel Bachurski, Ulrike Koitzsch, Uta Drebber, Esther Mahabir, Hinrich P. Hansen, Scott L. Friedman, Sabine Klein, Hans Peter Dienes, Marianna Hoesel, Reinhard Büttner, Jonel Trebicka, Vangelis Kondylis, Inge Mannaerts, Margarete Odenthal. Autophagy-related activation of hepatic stellate cells reduces cellular miR-29a by promoting its vesicular secretion. Cellular and Molecular Gastroenterology and Hepatology, available online 24 February 2022

Locy H, Verhulst S, Cools W, Waelput W, Brock S, Cras L, Schiettecatte A, Jonckheere J, van Grunsven LA, Vanhoeij M, Thielemans K, Breckpot K. Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring. Front Immunol. 2022 Feb 11;13:794175. doi: 10.3389/fimmu.2022.794175. eCollection 2022.

Herrero A, Knetemann E, Mannaerts I. Challenges of In Vitro CAF Modelling in Liver Cancers. Cancers 2021, 13(23), 5914; https://doi.org/10.3390/cancers13235914. Review

De Smet V, Eysackers N, Merens V, Kazemzadeh Dastjerd M, Halder G, Verhulst S, Mannaerts I, van Grunsven LA. Initiation of hepatic stellate cell activation extends into chronic liver disease. Cell Death Dis. 2021 Nov 27;12(12):1110. doi: 10.1038/s41419-021-04377-1.

Verhulst S, Van Os EA, De Smet V, Eysackers N, Mannaerts I, van Grunsven LA. Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases. https://doi.org/10.3389/fmed.2021.750044

Kumar M, Toprakhisar B, Van Haele M, Antoranz A, Boon R, Chesnais F, De Smedt J, Tricot T, Idoype TI, Canella M, Tilliole P, De Boeck J, Bajaj M, Ranga A, Bosisio FM, Roskams T, van Grunsven LA, Verfaillie CM. A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model. Biomaterials. 2021 Sep;276:121006. doi: 10.1016/j.biomaterials.2021.121006. Epub 2021 Jul 9

Vandewalle J, Timmermans S, Paakinaho V, Vancraeynest L, Dewyse L, Vanderhaeghen T, Wallaeys C, Van Wyngene L, Van Looveren K, Nuyttens L, Eggermont M, Dewaele S, Velho TR, Moita LF, Weis S, Sponholz C, van Grunsven LA, Dewerchin M, Carmeliet P, De Bosscher K, Van de Voorde J, Palvimo JJ, Libert C. Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis.Cell Metab. 2021 Sep 7;33(9):1763-1776.e5. doi: 10.1016/j.cmet.2021.07.002. Epub 2021 Jul 23.

Dewyse L, Reynaert H, van Grunsven LA. Best Practices and Progress in Precision-Cut Liver Slice Cultures. Int J Mol Sci. 2021 Jul 1;22(13):7137. doi: 10.3390/ijms22137137.

Vallverdú J, Martínez García de la Torre RA, Mannaerts I, Verhulst S, Smout A, Coll M, Ariño S, Rubio-Tomás T, Aguilar-Bravo B, Martínez-Sánchez C, Blaya D, Verfaillie CM, van Grunsven LA, Sancho-Bru P. Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells. Nat Protoc. 2021 May;16(5):2542-2563. doi: 10.1038/s41596-021-00509-1. Epub 2021 Apr 16.

Rombaut M, Boeckmans J, Rodrigues RM, van Grunsven LA, Vanhaecke T, De Kock J. Direct reprogramming of somatic cells into induced hepatocytes: cracking the Enigma code. J Hepatol. 2021 May 11:S0168-8278(21)00314-7. doi: 10.1016/j.jhep.2021.04.048. Online ahead of print.

de Haan W, Dheedene W, Apelt K, Décombas-Deschamps S, Vinckier S, Verhulst S, Conidi A, Deffieux T, Staring MW, Vandervoort P, Caluwé E, Lox M, Mannaerts I, Takagi T, Jaekers J, Berx G, Haigh J, Topal B, Zwijsen A, Higashi Y, van Grunsven LA, van IJcken WFJ, Mulugeta E, Tanter M, Lebrin FPG, Huylebroeck D, Luttun A. Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis. Cardiovasc Res. 2021 Apr 28:cvab148. doi: 10.1093/cvr/cvab148. Online ahead of print.

De Smedt J, van Os EA, Talon I, Ghosh S, Toprakhisar B, Madeiro Da Costa R, Zaunz S, Vazquez MA, Boon R, Baatsen P, Smout A, Verhulst S, van Grunsven LA, Verfaillie CM. PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells. Cell Death Dis. 2021 Jan 14;12(1):84. doi: 10.1038/s41419-020-03356-2.

Verboven E, Moya IM, Sansores-Garcia L, Xie J, Hillen H, Kowalczyk W, Vella G, Verhulst S, Castaldo SA, Algueró-Nadal A, Romanelli L, Mercader-Celma C, Souza NA, Soheily S, van Huffel L, Van Brussel T, Lambrechts D, Roskams T, Lemaigre FP, Bergers G, van Grunsven LA, Halder G. Regeneration Defects in Yap and Taz Mutant Mouse Livers are Caused by Bile Duct Disruption and Cholestasis. Gastroenterology. 2020 Oct 27;S0016-5085(20)35324-5. doi: 10.1053/j.gastro.2020.10.035. Online ahead of print

Mannaerts I, Eysackers N, Anne van Os E, Verhulst S, Roosens T, Smout A, Hierlemann A, Frey O, Leite SB, van Grunsven LA. The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation. Biomaterials. 2020 Dec;261:120335. doi: 10.1016/j.biomaterials.2020.120335. Epub 2020 Aug 22.

Lambrecht J, van Grunsven LA, Tacke F. Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis. Expert Opin Pharmacother. 2020 Sep;21(13):1637-1650. doi: 10.1080/14656566.2020.1774553. Epub 2020 Jun 16.

De Smet V, Verhulst S, van Grunsven LA. Single Cell RNA Sequencing Analysis Did Not Predict Hepatocyte Infection by SARS-CoV-2. J Hepatol. 2020 May 27:S0168-8278(20)30349-4. doi: 10.1016/j.jhep.2020.05.030. Online ahead of print.

Verbeeck A, De Becker A, Reynaert H. An Unexpected Cause of Recurrent Jaundice after Resolution of Acute Hepatitis E. Case Rep Gastroenterol. 2020 Aug 14;14(2):415-419. doi: 10.1159/000508425. eCollection 2020 May-Aug.

Moya IM, Castaldo SA, Van den Mooter L, Soheily S, Sansores-Garcia L, Jacobs J, Mannaerts I, Xie J, Verboven E, Hillen H, Algueró-Nadal A, Karaman R, Van Haele M, Kowalczyk W, De Waegeneer M, Verhulst S, Karras P, van Huffel L, Zender L, Marine JC, Roskams T, Johnson R, Aerts S, van Grunsven LA, Halder G. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019 Nov 22;366(6468):1029-1034. doi: 10.1126/science.aaw9886.

Reynaert H, Colle I. Treatment of Advanced Hepatocellular Carcinoma with Somatostatin Analogues: A Review of the Literature. Int J Mol Sci. 2019 Sep 27;20(19):4811. doi: 10.3390/ijms20194811.

Bonnardel J, T'Jonck W, Gaublomme D, Browaeys R, Scott CL, Martens L, Vanneste B, De Prijck S, Nedospasov SA, Kremer A, Van Hamme E, Borghgraef P, Toussaint W, De Bleser P, Mannaerts I, Beschin A, van Grunsven LA, Lambrecht BN, Taghon T, Lippens S, Elewaut D, Saeys Y, Guilliams M. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Immunity. 2019 Sep 24. pii: S1074-7613(19)30368-1. doi: 10.1016/j.immuni.2019.08.017. [Epub ahead of print]

Verhulst S, Roskams T, Sancho-Bru P, van Grunsven LA. Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles. Cells 2019, 8(10), 1117; https://doi.org/10.3390/cells8101117

Lambrecht J, Verhulst S, Reynaert H, van Grunsven LA. The miRFIB-Score: A Serological miRNA-Based Scoring Algorithm for the Diagnosis of Significant Liver Fibrosis. Cells. 2019 Aug 29;8(9). pii: E1003. doi: 10.3390/cells8091003

Troisi RI, Vanlander A, Giglio MC, Van Limmen J, Scudeller L, Heyse B, De Baerdemaeker L, Croo A, Voet D, Praet M, Hoorens A, Antoniali G, Codarin E, Tell G, Reynaert H, Colle I, Sainz-Barriga M. Somatostatin as Inflow Modulator in Liver-transplant Recipients With Severe Portal Hypertension: A Randomized Trial. Ann Surg. 2019 Jun;269(6):1025-1033. doi: 10.1097/SLA.0000000000003062.

Lambrecht J, Verhulst S, Mannaerts I, Sowa JP, Best J, Canbay A, Reynaert H, van Grunsven LA. A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease. EBioMedicine. 2019 May;43:501-512. doi: 10.1016/j.ebiom.2019.04.036. Epub 2019 Apr 27.

Manco R, Clerbaux LA, Verhulst S, Bou Nader M, Sempoux C, Ambroise J, Bearzatto B, Gala JL, Horsmans Y, van Grunsven L, Desdouets C, Leclercq I. Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury. J Hepatol. 2019 Jun;70(6):1180-1191. doi: 10.1016/j.jhep.2019.02.003. Epub 2019 Feb 20.

Lesaffer B, Verboven E, Van Huffel L, Moya IM, van Grunsven LA, Leclercq IA, Lemaigre FP, Halder G. Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers. Cells. 2019 Apr 25;8(4). pii: E380. doi: 10.3390/cells8040380.

Mannaerts I, Thoen LFR, Eysackers N, Cubero FJ, Batista Leite S, Coldham I, Colle I, Trautwein C, van Grunsven LA. Unfolded protein response is an early, non-critical event during hepatic stellate cell activation. Cell Death Dis. 2019 Feb 4;10(2):98. doi: 10.1038/s41419-019-1327-5.

Motté E, Pipeleers L, Wilgenhof K, Reynaert H, Urbain D, Mana F. Terminal ileitis after kidney transplantation : Crohn's disease or other? Case reports and literature review. Acta Gastroenterol Belg. 2019 Jan-Mar;82(1):63-66. Review.

Huysentruyt K, Van De Maele K, Hauser B, Reynaert H, Mana F, Vandenplas Y. Argon Plasma Coagulation as a Treatment of Multiple Esophageal Papillomata in a Girl With Goltz Syndrome. J Pediatr Gastroenterol Nutr. 2019 Jan;68(1):e13. doi: 10.1097/MPG.0000000000002116.

Najar M, Crompot E, van Grunsven LA, Dollé L, Lagneaux L. Aldehyde dehydrogenase activity of Wharton jelly mesenchymal stromal cells: isolation and characterization. Cytotechnology. 2019 Jan 4. doi: 10.1007/s10616-018-0283-8. [Epub ahead of print]

Stradiot L, Mannaerts I, van Grunsven LA. P311, Friend, or Foe of Tissue Fibrosis? Front Pharmacol. 2018 Oct 12;9:1151. doi: 10.3389/fphar.2018.01151. eCollection 2018.

Coll M, Perea L, Boon R, Leite SB, Vallverdú J, Mannaerts I, Smout A, El Taghdouini A, Blaya D, Rodrigo-Torres D, Graupera I, Aguilar-Bravo B, Chesne C, Najimi M, Sokal E, Lozano JJ, van Grunsven LA, Verfaillie CM, Sancho-Bru P. Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis. Cell Stem Cell. 2018 Jul 5;23(1):101-113.e7. doi: 10.1016/j.stem.2018.05.027. Epub 2018 Jun 28.

Najar M, Crompot E, van Grunsven LA, Dollé L, Lagneaux L. Foreskin-derived mesenchymal stromal cells with aldehyde dehydrogenase activity: isolation and gene profiling.BMC Cell Biol. 2018 Apr 6;19(1):4. doi: 10.1186/s12860-018-0157-0.

Najar M, Crompot E, van Grunsven LA, Dollé L, Lagneaux L. Aldehyde Dehydrogenase Activity in Adipose Tissue: Isolation and Gene Expression Profile of Distinct Sub-population of Mesenchymal Stromal Cells. Stem Cell Rev. 2018 Aug;14(4):599-611. doi: 10.1007/s12015-017-9777-6.

Van Hees S, Bourgeois S, Van Vlierberghe H, Sersté T, Francque S, Michielsen P, Sprengers D, Reynaert H, Henrion J, Negrin Dastis S, Delwaide J, Lasser L, Decaestecker J, Orlent H, Janssens F, Robaeys G, Colle I, Stärkel P, Moreno C, Nevens F, Vanwolleghem T; Belgian NA Stop Study Group. Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes. Aliment Pharmacol Ther. 2018 Apr;47(8):1170-1180. doi: 10.1111/apt.14560. Epub 2018 Mar 2.

Lambrecht J, Verhulst S, Mannaerts I, Reynaert H, van Grunsven LA. Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future gold standard? Biochim Biophys Acta. 2018 Apr;1864(4 Pt A):1024-1036. doi: 10.1016/j.bbadis.2018.01.009. Epub 2018 Jan 9. Review.

De Smedt E, Maes K, Verhulst S, Lui H, Kassambara A, Maes A, Robert N, Heirman C, Cakana A, Hose D, Breckpot K, van Grunsven LA, De Veirman K, Menu E, Vanderkerken K, Moreaux J, De Bruyne E. Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression. Cancer Res. 2018 Mar 1;78(5):1155-1168. doi: 10.1158/0008-5472.CAN-17-1544. Epub 2017 Dec 19.

Motté E, Pipeleers L, Wilgenhof K, Reynaert H, Urbain D, Mana F. Terminal ileitis after kidney transplantation : Crohn's disease or other? Case reports and literature review. Acta Gastroenterol Belg. 2019 Jan-Mar;82(1):63-66. Review.

De Smedt E, Maes K, Verhulst S, Lui H, Kassambara A, Maes A, Robert N, Heirman C, Cakana A, Hose D, Breckpot K, van Grunsven LA, De Veirman K, Menu E, Vanderkerken K, Moreaux J, De Bruyne E. Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression. Cancer Res. 2018 Mar 1;78(5):1155-1168. doi: 10.1158/0008-5472.CAN-17-1544. Epub 2017 Dec 19.

Willebrords J, Maes M, Pereira IVA, da Silva TC, Govoni VM, Lopes VV, Crespo Yanguas S, Shestopalov VI, Nogueira MS, de Castro IA, Farhood A, Mannaerts I, van Grunsven L, Akakpo J, Lebofsky M, Jaeschke H, Cogliati B, Vinken M. Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):819-830. doi: 10.1016/j.bbadis.2017.12.013. Epub 2017 Dec 12.

Najar M, Fayyad-Kazan H, Faour WH, El Taghdouini A, Raicevic G, van Grunsven LA, Najimi M, Sokal E, Lagneaux L. Immuno-biological comparison of hepatic stellate cells in a reverted and activated state.Biomed Pharmacother. 2018 Feb;98:52-62. doi: 10.1016/j.biopha.2017.12.027. Epub 2017 Dec 12.

Najar M, Dollé L, Crompot E, Verhulst S, van Grunsven LA, Busser H, Lagneaux L. Isolation and Characterization of Bone Marrow Mesenchymal Stromal Cell Subsets in Culture Based on Aldehyde Dehydrogenase Activity. Tissue Eng Part C Methods. 2018 Feb;24(2):89-98. doi: 10.1089/ten.TEC.2017.0312. Epub 2018 Jan 16.

Aerts M, Reynaert H. Disease Control on Lanreotide Autogel® 120 mg in a Patient with Metastatic Gastrinoma: A Case Report. Case Rep Gastroenterol. 2017 Dec 6;11(3):616-623. doi: 10.1159/000485025. eCollection 2017 Sep-Dec.

Ceulemans A, Verhulst S, Van Haele M, Govaere O, Ventura JJ, van Grunsven LA, Roskams T. RNA-sequencing-based comparative analysis of human hepatic progenitor cells and their niche from alcoholic steatohepatitis livers. Cell Death Dis. 2017 Nov 2;8(11):e3164. doi: 10.1038/cddis.2017.543.

van Grunsven LA. 3D in vitro models of liver fibrosis. Adv Drug Deliv Rev. 2017 Nov 1;121:133-146. doi: 10.1016/j.addr.2017.07.004. Epub 2017 Jul 8. Review.

Stradiot L, Verhulst S, Roosens T, Øie CI, Moya IM, Halder G, Mannaerts I, van Grunsven LA. Functionality based method for simultaneous isolation of rodent hepatic sinusoidal cells. Biomaterials. 2017 Sep;139:91-101. doi: 10.1016/j.biomaterials.2017.05.047. Epub 2017 May 30.

Najimi M, Berardis S, El-Kehdy H, Rosseels V, Evraerts J, Lombard C, El Taghdouini A, Henriet P, van Grunsven L, Sokal EM. Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation. Stem Cell Res Ther. 2017 Jun 5;8(1):131. doi: 10.1186/s13287-017-0575-5.

Perea L, Coll M, Sanjurjo L, Blaya D, Taghdouini AE, Rodrigo-Torres D, Altamirano J, Graupera I, Aguilar-Bravo B, Llopis M, Vallverdú J, Caballeria J, van Grunsven LA, Sarrias MR, Ginès P, Sancho-Bru P. Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury. Hepatology. 2017 Sep;66(3):953-968. doi: 10.1002/hep.29215. Epub 2017 Jul 18.

Dollé L. Pharmacological enrollment of aldehyde dehydrogenase modulators to assist treating ischemia reperfusion-induced intestinal injury: is there a gap to be bridged?Clin Sci (Lond). 2017 May 22;131(11):1137-1140. doi: 10.1042/CS20170163. Print 2017 Jun 1.

Lambrecht J, Jan Poortmans P, Verhulst S, Reynaert H, Mannaerts I, van Grunsven LA. Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis. Front Pharmacol. 2017 Feb 9;8:56. doi: 10.3389/fphar.2017.00056. eCollection 2017.

Paridaens A, Raevens S, Devisscher L, Bogaerts E, Verhelst X, Hoorens A, Van Vlierberghe H, van Grunsven LA, Geerts A, Colle I. Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis. Int J Mol Sci. 2017 Jan 20;18(1). pii: E214. doi: 10.3390/ijms18010214.

Najar M, Fayyad-Kazan H, Faour WH, El Taghdouini A, Raicevic G, Najimi M, Toungouz M, van Grunsven LA, Sokal E, Lagneaux L. Human hepatic stellate cells and inflammation: A regulated cytokine network balance. Cytokine. 2017 Feb;90:130-134. doi: 10.1016/j.cyto.2016.11.008.

Best J, Bilgi H, Heider D, Schotten C, Manka P, Bedreli S, Gorray M, Ertle J, van Grunsven LA, Dechêne A. The GALAD scoring algorithm based on AFP, AFP-L3, and DCP significantly improves detection of BCLC early stage hepatocellular carcinoma. Z Gastroenterol. 2016 Dec;54(12):1296-1305.

Verhulst S, Best J, Syn WK, Reynaert H, Hellemans KH, Canbay A, Dolle L, van Grunsven LA. Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice. Sci Rep. 2016 Nov 8;6:36586. doi: 10.1038/srep36586.

El Taghdouini A, van Grunsven LA. Epigenetic regulation of hepatic stellate cell activation and liver fibrosis.Expert Rev Gastroenterol Hepatol. 2016 Oct 20.

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld F, Goossens S, Haigh JJ, Huylebroeck D. Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.Stem Cells. 2016 Oct 14. doi: 10.1002/stem.2521

Paridaens A, Raevens S, Colle I, Bogaerts E, Vandewynckel YP, Verhelst X, Hoorens A, van Grunsven LA, Van Vlierberghe H, Geerts A, Devisscher L. Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication. Liver Int. 2016 Oct 5. doi: 10.1111/liv.13261.

Verbeke L, Mannaerts I, Schierwagen R, Govaere O, Klein S, Vander Elst I, Windmolders P, Farre R, Wenes M, Mazzone M, Nevens F, van Grunsven LA, Trebicka J, Laleman W. FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis. Sci Rep. 2016 Sep 16;6:33453. doi: 10.1038/srep33453.

Best J, Verhulst S, Syn WK, Lagaisse K, van Hul N, Heindryckx F, Sowa JP, Peeters L, Van Vlierberghe H, Leclercq IA, Canbay A, Dollé L, van Grunsven LA. Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies. PLoS One. 2016 Sep 12;11(9):e0162286. doi: 10.1371/journal.pone.0162286. eCollection 201

Boens S, Verbinnen I, Verhulst S, Szekér K, Ferreira M, Gevaert T, Baes M, Roskams T, van Grunsven LA, Van Eynde A, Bollen M. Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver. Stem Cells. 2016 Aug;34(8):2256-62. doi: 10.1002/stem.2375. Epub 2016 Jun 20.

Huch M, Dollé L. The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose? Hepatology. 2016 Aug;64(2):652-62. doi: 10.1002/hep.28469. Epub 2016 Mar 17. Review.

Dollé L, Tran HQ, Etienne-Mesmin L, Chassaing B. Policing of gut microbiota by the adaptive immune system. BMC Med. 2016 Feb 12;14:27. doi: 10.1186/s12916-016-0573-y.

Leite SB, Roosens T, El Taghdouini A, Mannaerts I, Smout AJ, Najimi M, Sokal E, Noor F, Chesne C, van Grunsven LA. Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials. 2016 Feb;78:1-10. doi: 10.1016/j.biomaterials.2015.11.026. Epub 2015 Nov 17.

Govaere O, Wouters J, Petz M, Vandewynckel YP, Van den Eynde K, Van den Broeck A, Verhulst S, Dollé L, Gremeaux L, Ceulemans A, Nevens F, van Grunsven LA, Topal B, Vankelecom H, Giannelli G, Van Vlierberghe H, Mikulits W, Komuta M, Roskams T. Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche. J Hepatol. 2016 Mar;64(3):609-17. doi: 10.1016/j.jhep.2015.11.011. Epub 2015 Nov 17.

Dollé L, Gilgenkrantz H. [Axin-2+ hepatocytes are better at maintaining liver mass]. Med Sci (Paris). 2015 Dec;31(12):1069-71. doi: 10.1051/medsci/20153112007. Epub 2015 Dec 16. French.

Coombes JD, Choi SS, Swiderska-Syn M, Manka P, Reid DT, Palma E, Briones-Orta MA, Xie G, Younis R, Kitamura N, Della Peruta M, Bitencourt S, Dollé L, Oo YH, Mi Z, Kuo PC, Williams R, Chokshi S, Canbay A, Claridge LC, Eksteen B, Diehl AM, Syn WK. Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis. Biochim Biophys Acta. 2016 Jan;1862(1):135-44. doi: 10.1016/j.bbadis.2015.10.028. Epub 2015 Oct 31.

Verhulst S, Best J, van Grunsven LA, Dollé L. Advances in hepatic stem/progenitor cell biology. EXCLI J. 2015 Jan 6;14:33-47. doi: 10.17179/excli2014-576. eCollection 2015. Review.

El Taghdouini A, Sørensen AL, Reiner AH, Coll M, Verhulst S, Mannaerts I, Øie CI, Smedsrød B, Najimi M, Sokal E, Luttun A, Sancho-Bru P, Collas P, van Grunsven LA. Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells. Oncotarget. 2015 Aug 31. [Epub ahead of print]

El Taghdouini A, Najimi M, Sancho-Bru P, Sokal E, van Grunsven LA. In vitro reversion of activated primary human hepatic stellate cells. Fibrogenesis Tissue Repair. 2015 Aug 6;8:14. doi: 10.1186/s13069-015-0031-z. eCollection 2015.

Lambrecht J, Mannaerts I, van Grunsven LA. The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis. Front Physiol. 2015 Jul 28;6:209. doi: 10.3389/fphys.2015.00209. eCollection 2015.

Coll M, Taghdouini AE, Perea L, Mannaerts I, Vila-Casadesús M, Blaya D, Rodrigo-Torres D, Affò S, Morales-Ibanez O, Graupera I, Lozano JJ, Najimi M, Sokal E, Lambrecht J, Ginès P, van Grunsven LA, Sancho-Bru P. Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells. Sci Rep. 2015 Jun 22;5:11549. doi: 10.1038/srep11549.

Dollé L, de La Serre C, van Grunsven LA. Are dietary emulsifiers making us fat? J Hepatol. 2015 Jun 18. pii: S0168-8278(15)00395-5. doi: 10.1016/j.jhep.2015.06.005. [Epub ahead of print]

Mannaerts I, Leite SB, Verhulst S, Claerhout S, Eysackers N, Thoen LF, Hoorens A, Reynaert H, Halder G, van Grunsven LA. The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J Hepatol. 2015 Apr 20. pii: S0168-8278(15)00294-9. doi: 10.1016/j.jhep.2015.04.011. [Epub ahead of print]

Bogaerts E, Heindryckx F, Devisscher L, Paridaens A, Vandewynckel YP, Van den Bussche A, Verhelst X, Libbrecht L, van Grunsven LA, Geerts A, Van Vlierberghe H. Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors. PLoS One. 2015 Mar 20;10(3):e0119555. doi: 10.1371/journal.pone.0119555. eCollection 2015.

Bitencourt S, Stradiot L, Verhulst S, Thoen L, Mannaerts I, van Grunsven LA. Inhibitory effect of dietary capsaicin on liver fibrosis in mice. Mol Nutr Food Res. 2015 Jun;59(6):1107-16. doi: 10.1002/mnfr.201400649. Epub 2015 Apr 29.

Maus J, Mana F, Reynaert H, Urbain D. Distal intestinal obstruction in CF patients. Acta Gastroenterol Belg. 2015 Jan-Mar;78(1):49-52.

Dusabineza AC, Najimi M, van Hul N, Legry V, Khuu DN, van Grunsven LA, Sokal E, Leclercq IA. Hepatic stellate cells improve engraftment of human primary hepatocytes: A pre-clinical transplantation study in animal model. Cell Transplant. 2015 Feb 20. doi: 10.3727/096368915X686788.

Best J, Manka P, Syn WK, Dollé L, van Grunsven LA, Canbay A. Role of liver progenitors in liver regeneration. Hepatobiliary Surg Nutr. 2015 Feb;4(1):48-58. doi: 10.3978/j.issn.2304-3881.2015.01.16.

Dollé L, Gao B. Pharmacological Chaperone Therapies: Can Aldehyde Dehydrogenase Activator Make Us Healthier? J Hepatol. 2015 Feb 11. pii: S0168-8278(15)00085-9. doi: 10.1016/j.jhep.2015.02.011. [Epub ahead of print]

Dollé L, Boulter L, Leclercq IA, van Grunsven LA. Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 5:ajpgi.00420.2014. doi: 10.1152/ajpgi.00420.2014. [Epub ahead of print]

Dollé L, Theise ND, Schmelzer E, Boulter L, Gires O, van Grunsven LA. EpCAM and the biology of hepatic stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G233-G250. doi: 10.1152/ajpgi.00069.2014. Epub 2014 Dec 4. Review.

Raicevic G, Najar M, Najimi M, El Taghdouini A, van Grunsven LA, Sokal E, Toungouz M. Influence of inflammation on the immunological profile of adult-derived human liver mesenchymal stromal cells and stellate cells. Cytotherapy. 2015 Feb;17(2):174-85. doi: 10.1016/j.jcyt.2014.10.001. Epub 2014 Nov 21.

Guimarães EL, Stradiot L, Mannaerts I, Schroyen B, van Grunsven LA. P311 modulates hepatic stellate cells migration. Liver Int. 2014 Sep 19. doi: 10.1111/liv.12691. [Epub ahead of print]

Gevaert E, Dollé L, Billiet T, Dubruel P, van Grunsven L, van Apeldoorn A, Cornelissen R. High throughput micro-well generation of hepatocyte micro-aggregates for tissue engineering. PLoS One. 2014 Aug 18;9(8):e105171. doi: 10.1371/journal.pone.0105171. eCollection 2014.

Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, Canbay A, Adams DH, Diehl AM, van Grunsven LA, Choi SS, Syn WK. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. Gut. 2014 Jun 5. pii: gutjnl-2013-306484

Rodrigo-Torres D, Affò S, Coll M, Morales-Ibanez O, Millán C, Blaya D, Alvarez-Guaita A, Rentero C, Lozano JJ, Maestro MA, Solar M, Arroyo V, Caballería J, van Grunsven LA, Enrich C, Ginès P, Bataller R, Sancho-Bru P.The biliary epithelium gives rise to liver progenitor cells.Hepatology. 2014 Feb 20. doi: 10.1002/hep.27078. [Epub ahead of print]

Bragança de Moraes CM, Bitencourt S, de Mesquita FC, Mello D, de Oliveira LP, da Silva GV, Lorini V, Caberlon E, de Souza Basso B, Schmid J, Ferreira GA, de Oliveira JR. (+)-Catechin attenuates activation of hepatic stellate cells. Cell Biol Int. 2014 Apr;38(4):526-30. doi: 10.1002/cbin.10228. Epub 2014 Jan 10.

Paganelli M, Nyabi O, Sid B, Evraerts J, El Malmi I, Heremans Y, Dollé L, Benton C, Calderon PB, van Grunsven L, Heimberg H, Campard D, Sokal E, Najimi M. Downregulation of Sox9 Expression Associates with Hepatogenic Differentiation of Human Liver Mesenchymal Stem/Progenitor Cells. Stem Cells Dev. 2014 May 5. [Epub ahead of print]

Bitencourt S, Mesquita F, Basso B, Schmid J, Ferreira G, Rizzo L, Bauer M, Bartrons R, Ventura F, Rosa JL, Mannaerts I, van Grunsven LA, Oliveira J. Capsaicin Modulates Proliferation, Migration, and Activation of Hepatic Stellate Cells. Cell Biochem Biophys. 2014 Mar;68(2):387-96. doi: 10.1007/s12013-013-9719-0.

Bessems JG, Loizou G, Krishnan K, Clewell HJ 3rd, Bernasconi C, Bois F, Coecke S, Collnot EM, Diembeck W, Farcal LR, Geraets L, Gundert-Remy U, Kramer N, Küsters G, Leite SB, Pelkonen OR, Schröder K, Testai E, Wilk-Zasadna I, Zaldívar-Comenges JM. PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop. Regul Toxicol Pharmacol. 2014 Feb;68(1):119-39. doi: 10.1016/j.yrtph.2013.11.008. Epub 2013 Nov 26.

Berardis S, Lombard C, Evraerts J, El Taghdouini A, Rosseels V, Sancho-Bru P, Lozano JJ, van Grunsven L, Sokal E, Najimi M. Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells. PLoS One. 2014 Jan 21;9(1):e86137. doi: 10.1371/journal.pone.0086137. eCollection 2014.

Bogaerts E, Heindryckx F, Vandewynckel YP, Van Grunsven LA, Van Vlierberghe H. The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review). Int J Oncol. 2014 Apr;44(4):1015-22. doi: 10.3892/ijo.2014.2286. Epub 2014 Feb 3

Mannaerts I, Schroyen B, Verhulst S, Van Lommel L, Schuit F, Nyssen M, van Grunsven LA. Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration. PLoS One. 2013 Dec 17;8(12):e84071.

Mfopou, J.K., Geeraerts, M., Dejene, R., Van Langenhoven, S., Aberkane, A., Van Grunsven, L.A., and Bouwens, L. (2014). Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies. Stem Cell Res 12, 166-177. IF 2012: 4.467 IF = 4.4

de Mesquita FC, Bitencourt S, Caberlon E, da Silva GV, Basso BS, Schmid J, Ferreira GA, de Oliveira Fdos S, de Oliveira JR. Fructose-1,6-bisphosphate induces phenotypic reversion of activated hepatic stellate cell. Eur J Pharmacol. 2013 Nov 15;720(1-3):320-5. doi: 10.1016/j.ejphar.2013.09.067. Epub 2013 Oct 19.

Ketkar-Atre A, Struys T, Dresselaers T, Hodenius M, Mannaerts I, Ni Y, Lambrichts I, Van Grunsven LA, De Cuyper M, Himmelreich U. In vivo hepatocyte MR imaging using lactose functionalized magnetoliposomes. Biomaterials. 2014 Jan;35(3):1015-24. doi: 10.1016/j.biomaterials.2013.10.029. Epub 2013 Nov 5.

Best J, Dollé L, Manka P, Coombes J, van Grunsven LA, Syn WK. Role of liver progenitors in acute liver injury. Front Physiol. 2013 Sep 26;4:258. eCollection 2013.

Van Rossen E, Liu Z, Blijweert D, Eysackers N, Mannaerts I, Schroyen B, El Taghdouini A, Edwards B, Davies KE, Sokal E, Najimi M, Reynaert H, van Grunsven LA. Syncoilin is an intermediate filament protein in activated hepatic stellate cells. Histochem Cell Biol. 2013 Sep 17. [Epub ahead of print]

Govaere O, Komuta M, Berkers J, Spee B, Janssen C, de Luca F, Katoonizadeh A, Wouters J, van Kempen LC, Durnez A, Verslype C, De Kock J, Rogiers V, van Grunsven LA, Topal B, Pirenne J, Vankelecom H, Nevens F, van den Oord J, Pinzani M, Roskams T. Keratin 19: a key role player in the invasion of human hepatocellular carcinomas. Gut. 2013 Aug 19. [Epub ahead of print]

Coecke S, Pelkonen O, Leite SB, Bernauer U, Bessems JG, Bois FY, Gundert-Remy U, Loizou G, Testai E, Zaldívar JM. Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches. Toxicol In Vitro. 2013 Aug;27(5):1570-7. doi: 10.1016/j.tiv.2012.06.012. Epub 2012 Jul 4. Review.

Theise ND, Dollé L, Kuwahara R. Low hepatocyte repopulation from stem cells: a matter of hepatobiliary linkage not massive production. Gastroenterology. 2013 Jul;145(1):253-4. doi: 10.1053/j.gastro.2013.02.052. Epub 2013 May 31.

Van Beneden K, Geers C, Pauwels M, Mannaerts I, Wissing KM, Van den Branden C, van Grunsven LA. Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. Toxicol Appl Pharmacol. 2013 Sep 1;271(2):276-84. Epub 2013 May 22.

Mannaerts I, Eysackers N, Onyema OO, Van Beneden K, Valente S, Mai A, Odenthal M, van Grunsven LA. Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29. PLoS One. 2013;8(1):e55786. Epub 2013 Jan 31.

Van Beneden K, Mannaerts I, Pauwels M, Van den Branden C, van Grunsven LA.HDAC inhibitors in experimental liver and kidney fibrosis. Fibrogenesis Tissue Repair. 2013 Jan 2;6(1):1.

Leite SB, Wilk-Zasadna I, Zaldivar JM, Airola E, Reis-Fernandes MA, Mennecozzi M, Guguen-Guillouzo C, Chesne C, Guillou C, Alves PM, Coecke S. Three-dimensional HepaRG model as an attractive tool for toxicity testing. Toxicol Sci. 2012 Nov;130(1):106-16. doi: 10.1093/toxsci/kfs232. Epub 2012 Jul 27

Kaldenbach M, Giebeler A, Tschaharganeh DF, Erschfeld S, Wasmuth HE, Dolle L, Floege J, Trautwein C, Streetz KL. Hepatocyte growth factor/c-Met signalling is important for the selection of transplanted hepatocytes. Gut. 2012 Aug;61(8):1209-18. doi: 10.1136/gutjnl-2011-301345. Epub 2012 Jan 27

Klionsky DJ,... , van Grunsven LA,... Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544.

Van Valckenborgh E, Matsui W, Agarwal P, Lub S, Dehui X, De Bruyne E, Menu E, Empsen C,van Grunsven L, Agarwal J, Wang Q, Jernberg-Wiklund H, Vanderkerken K. Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model. Leukemia. 2012 Jun;26(6):1436-9.

Schroyen B, Guimarães EL, Dollé L, Coulon S, Empsen C, Nyssen M, Geerts A, Colle I, Geerts A, van Grunsven LA.Leptin-mediated reactive oxygen species production does not significantly affect primary mouse hepatocyte functions in vitro. Eur J Gastroenterol Hepatol. 2012 Dec;24(12):1370-80.

Guimarães EL, Best J, Dollé L, Najimi M, Sokal E, van Grunsven LA. Mitochondrial uncouplers inhibit hepatic stellate cell activation. BMC Gastroenterol. 2012 Jun 11;12(1):68.

Dollé L, Streetz KL, van Grunsven LA. Sharpen your look on liver progenitor cells. Hepatology. 2012 Jan;55(1):319-21.

Thoen LF, Guimarães EL, van Grunsven LA. Autophagy: A new player in hepatic stellate cell activation. Autophagy. 2012 Jan 1;8(1). [Epub ahead of print]

Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J. Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway. Lab Invest. 2012 Jan;92(1):57-71.

Buyens K, De Smedt SC, Braeckmans K, Demeester J, Peeters L, van Grunsven LA, de Mollerat du Jeu X, Sawant R, Torchilin V, Farkasova K, Ogris M, Sanders NN. Liposome based systems for systemic siRNA delivery: Stability in blood sets the requirements for optimal carrier design. J Control Release. 2012 Mar 28;158(3):362-70. Epub 2011 Oct 14.

Dollé L, Best J, Empsen C, Mei J, Van Rossen E, Roelandt P, Snykers S, Najimi M, Battah FA, Theise ND, Streetz K, Sokal E, Leclercq IA, Verfaillie C, Rogiers V, Geerts A, van Grunsven LA. Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity from naïve mice. Hepatology. 2011 Sep 27. doi: 10.1002/hep.24693. [Epub ahead of print]

Vanhooren V, Dewaele S, Kuro-O M, Taniguchi N, Dollé L, van Grunsven LA, Makrantonaki E, Zouboulis CC, Chen CC, Libert C. Alteration of N-glycomics during mouse aging: a role for FUT8. Aging Cell. 2011 Sep 23.doi: 10.1111/j.1474-9726.2011.00749.x. [Epub ahead of print]

Van Beneden K, Geers C, Pauwels M, Mannaerts I, Verbeelen D, van Grunsven LA, Van den Branden C. Valproic Acid attenuates proteinuria and kidney injury. J Am Soc Nephrol. 2011 Oct;22(10):1863-75. Epub 2011 Aug 25.

Thoen LF, Guimarães EL, Dollé L, Mannaerts I, Najimi M, Sokal E, van Grunsven LA. A role for autophagy during hepatic stellate cell activation. J Hepatol. 2011 Dec;55(6):1353-60. Epub 2011 Jul 29.

Orlent H, Reynaert H, Bourgeois S, Dideberg V, Adler M, Colle I, De Maeght S, Laleman W, Michielsen P, Moreno C, Mulkay JP, Stärkel P, Delwaide J; Belgian Association for the Study of the Liver. IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use? Acta Gastroenterol Belg. 2011 Jun;74(2):317-22. Review.

Steenkiste CV, Ribera J, Geerts A, Pauta M, Tugues S, Casteleyn C, Libbrecht L, Olievier K,Schroyen B, Reynaert H, van Grunsven LA, Blomme B, Coulon S, Heindryckx F, De Vos M, Stassen JM, Vinckier S, Altamirano J, Bataller R, Carmeliet P, Van Vlierberghe H, Colle I, Morales-Ruiz M. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Hepatology. 2011 May;53(5):1629-40. doi: 10.1002/hep.24238.

De Keersmaecker B, Heirman C, Corthals J, Empsen C, van Grunsven LA, Allard SD, Pen J, Lacor P, Thielemans K, Aerts JL. The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses. J Leukoc Biol. 2011 Jun;89(6):989-99. Epub 2011 Mar 22.

Tchouate Gainkam LO, Keyaerts M, Caveliers V, Devoogdt N, Vanhove C, Van Grunsven L, Muyldermans S, Lahoutte T. Correlation Between Epidermal Growth Factor Receptor-Specific Nanobody Uptake and Tumor Burden: A Tool for Noninvasive Monitoring of Tumor Response to Therapy. Mol Imaging Biol. 2011 Oct;13(5):940-8.

Z Liu, E Van Rossen, Jean-Pierre Timmermans, A Geerts, L A van Grunsven, H Reynaert. Distinct roles for non muscle myosin II isoforms in mouse hepatic stellate cells. J Hepatol. 2011 Jan;54(1):132-41. Epub 2010 Aug 26.

Urbain D, Aerts M, Reynaert H, Mana F, Neyns B. Small-bowel metastasis of malignant melanoma: video capsule endoscopy appearance. Endoscopy. 2010;42 Suppl 2:E185. Epub 2010 Aug 2.

Reynaert H, Dujardyn M, Urbain D. A star-spangled liver. Liver Int. 2010 Sep;30(8):1197.

Hall D, Poussin C, Velagapudi VR, Empsen C, Joffraud M, Beckmann J, Geerts AE, Ravussin Y, Ibberson M, Oresic M, Thorens B. Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. J Biol Chem. 2010 Oct 1;285(40):31011-23.

Guimarães ELM, Empsen C, Geerts A, van Grunsven LA. Advanced glycation end products induce production of reactive oxygen species via activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol. 2010 Mar;52(3):389-97.

Mannaerts I., Nuytten NR, Rogiers V, Vanderkerken K, van Grunsven LA and Geerts A. Chronic administration of sodium valproate inhibits activation of mouse hepatic stellate cells in vitro and in vivo. Hepatology. 2010 Feb;51(2):603-14

Z. Liu, L A. van Grunsven, E. Van Rossen, B. Schroyen, JP. Timmermans, A. Geerts, H. Reynaert. Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells. Br J Pharmacol. 2010 Jan 1;159(2):304-15.

Dollé L, Best J, Mei J, Al Battah F, Reynaert H, van Grunsven LA, Geerts A. The quest for liver progenitor cells: A practical point of view. J Hepatol. 2010 Jan;52(1):117-29.