Liver Cell Biology

In general, research projects at LIVR aim to better characterize the different liver cell types in healthy and pathological conditions, and to gain a better insight in the mechanisms of liver regeneration and the pathogenesis of liver fibrosis.

The LIVR team investigates:

• the mechanisms of liver fibrosis development and resolution
• the identification of hepatic stellate cell-specific biomarkers for liver fibrosis staging
• the generation of in vitro liver disease models
• iPSC derived liver cells for in vitro disease modeling
• the role for liver progenitor cells during liver regeneration

Long term objectives are:

• Contribute to the understanding of mechanisms involved in liver fibrosis
• Discover therapeutic targets for chronic liver diseases including non-alcoholic fatty liver disease (NAFLD).
• Develop in vitro models representative for human chronic liver disease