News & Events

"Human iPSC-derived liver co-culture spheroids to model liver fibrosis"  

"Orphan receptor GPR176 in hepatic stellate cells exerts a profibrotic role in chronic liver disease"  

Hippo signaling instructs ectopic but not normal organ growth.  W Kowalczyk, L Romanelli, M Atkins, H Hillen, C Bravo González-Blas, J Jacobs, J Xie, S Soheily, E Verboven  I M Moya, S Verhulst, M de Waegeneer, L Sansores-Ga...

Modelling fatty liver disease with mouse liver-derived multicellular spheroids   van Os EA, Cools L, Eysackers N, Szafranska K, Smout A, Verhulst S, Reynaert H, McCourt P, Mannaerts I, van Grunsven LA.   Biomaterials. 2022 Nov;290:121817.

      MORE SCIENCE, MORE CARE, LESS ANIMALS  

Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis    Liza Dewyse, Vincent De Smet, Stefaan Verhulst, Nathalie Eysackers, Rastislav Kunda, Nouredin Messaoudi, Hendrik Reynaert and Leo A.

VUB scientists Inge Mannaerts and Sofie Deschoemaeker have been awarded a prestigious four-year postdoctoral fellowship by the Stichting Tegen Kanker. Mannaerts received it for her research on tumours in the liver, and Deschoemaeker for her research on better treatment of breast cancer.

Initiation of hepatic stellate cell activation extends into chronic liver disease   Vincent De Smet, Nathalie Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, Georg Halder, Stefaan Verhulst, Inge Mannaerts & Leo A.

Submit your application here on Dec. 20th 2021 at the latest 

"Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases"   Verhulst S, Van Os EA, De Smet V, Eysackers N, Mannaerts I, van Grunsven LA.   

https://www.hln.be/binnenland/thibo-20-zag-zijn-levertransplantatie-uitgesteld-hierdoor-kreeg-ik-meerdere-complicaties-van-mijn-ziekte~aba444bf/  

Schrijf je in voor de Online ontmoetingsweek voor lagere scholen met o.m. een sessie door LIVR member Inge Mannaerts op  maandag 21 juni (+/- 1 uur):   "Je lever heeft superkrachten"  Wist je dat we allemaal een orgaan hebben met ‘superkrachten’?

Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells. Julia Vallverdú, Raquel A.

Direct reprogramming of somatic cells into induced hepatocytes: cracking the Enigma code. Matthias Rombaut, Joost Boeckmans, Robim M Rodrigues, Leo A van Grunsven, Tamara Vanhaecke, Joery De Kock   https://pubmed.ncbi.nlm.nih.gov/33989701/  https://www.jo...

Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis Willeke de Haan, Wouter Dheedene, Katerina Apelt, Sofiane Décombas-Deschamps, Stefan Vinckier, Stefaan Verhulst, Andrea Conidi, Thomas Deffieux, Michael W Staring...

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.

Regeneration Defects in Yap and Taz Mutant Mouse Livers are Caused by Bile Duct Disruption and Cholestasis     https://www.gastrojournal.org/article/S0016-5085(20)35324-5/pdf?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F  

The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation.    https://doi.org/10.1016/j.biomaterials.2020.120335  

https://today.vub.be/nl/artikel/vub-onderzoekers-waarschuwen-voor-gevaar-van-foute-conclusies-in-covid-19-levercelonderzoek  

Single cell RNA sequencing analysis did not predict hepatocyte infection by SARS-CoV-2  De Smet V, Verhulst S, van Grunsven LA. J Hepatol. 2020 May 27:S0168-8278(20)30349-4. doi: 10.1016/j.jhep.2020.05.030. Online ahead of print. 

Novel biomarkers for early stage live fibrosis     

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.

interview Stefaan Verhulst : on the impact of secondary school study results for a future academic career    

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.  

Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles. Cells 2019, 8(10), 1117; https://doi.org/10.3390/cells8101117  

The miRFIB-Score: A Serological miRNA-Based Scoring Algorithm for the Diagnosis of Significant Liver Fibrosis  

A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease  

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Joeri Lambrecht + Inge Mannaerts...

Joeri Lambrecht: The sPDGFR-beta containing PRTA-score is a novel diagnostic algorithm for significant liver fibrosis in patients with viral, alcoholic, and metabolic liver disease    Inge Mannaerts: Constructing a primary mouse 3D hepatic co-culture model that recapitulates HSC...

Publication: Cell Death Dis. 2019 Feb 4;10(2):98. doi: 10.1038/s41419-019-1327-5.

Publication: Cytotechnology. 2019 Jan 4. doi: 10.1007/s10616-018-0283-8. [Epub ahead of print]...

Publication: Front Pharmacol. 2018 Oct 12;9:1151

Liver Cell Biology Research Group...

Co-publication: BMC Cell Biol. 2018 Apr 6;19(1):4. doi: 10.1186/s12860-018-0157-0.

Co-Publication: Stem Cell Rev. 2018 Aug;14(4):599-611. doi: 10.1007/s12015-017-9777-6.

Review: Biochim Biophys Acta. 2018 Apr;1864(4 Pt A):1024-1036. doi: 10.1016/j.bbadis.2018.01.009. Epub 2018 Jan 9.