Biochim Biophys Acta. 2018 Apr;1864(4 Pt A):1024-1036. doi: 10.1016/j.bbadis.2018.01.009. Epub 2018 Jan 9.
Highlights
-
Early diagnosis and step-wise follow up of liver fibrosis is needed.
-
Current non-invasive diagnostic tools lack sufficient sensitivity and specificity.
-
Liquid biopsy might overcome current diagnostic limitations.
-
Circulating vesicles and free nucleic acids, proteins, and lipids as biomarkers
-
Limitations and possibilities of liquid biopsy in liver fibrosis